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The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity

Human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, contains conserved motifs common to retroviral reverse transcriptases and telomerases. Within the C motif of hTERT is the Leu866-Val867-Asp868-Asp869 tetrapeptide that includes a catalytically essential aspart...

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Autors principals: Drosopoulos, William C., Prasad, Vinayaka R.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851649/
https://ncbi.nlm.nih.gov/pubmed/17264120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm002
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