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The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity
Human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, contains conserved motifs common to retroviral reverse transcriptases and telomerases. Within the C motif of hTERT is the Leu866-Val867-Asp868-Asp869 tetrapeptide that includes a catalytically essential aspart...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2007
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1851649/ https://ncbi.nlm.nih.gov/pubmed/17264120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm002 |
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