IGF1R blockade with ganitumab results in systemic effects on the GH–IGF axis in mice

Ganitumab is a fully human MAB to the human type 1 IGF receptor (IGF1R). Binding assays showed that ganitumab recognized murine IGF1R with sub-nanomolar affinity (K(D)=0.22 nM) and inhibited the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab inhibited IGF1-induced activation of IGF1R in m...

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Hlavní autoři: Moody, Gordon, Beltran, Pedro J, Mitchell, Petia, Cajulis, Elaina, Chung, Young-Ah, Hwang, David, Kendall, Richard, Radinsky, Robert, Cohen, Pinchas, Calzone, Frank J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160154/
https://ncbi.nlm.nih.gov/pubmed/24492468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-13-0306
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