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IGF1R blockade with ganitumab results in systemic effects on the GH–IGF axis in mice
Ganitumab is a fully human MAB to the human type 1 IGF receptor (IGF1R). Binding assays showed that ganitumab recognized murine IGF1R with sub-nanomolar affinity (K(D)=0.22 nM) and inhibited the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab inhibited IGF1-induced activation of IGF1R in m...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160154/ https://ncbi.nlm.nih.gov/pubmed/24492468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-13-0306 |
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