Epitope-Specific Mechanisms of IGF1R Inhibition by Ganitumab

BACKGROUND: Therapeutic antibodies targeting the IGF1R have shown diverse efficacy and safety signals in oncology clinical trials. The success of these agents as future human therapeutics depends on understanding the specific mechanisms by which these antibodies target IGF1R signaling. METHODOLOGY/P...

Full description

Saved in:
Bibliographic Details
Main Authors: Calzone, Frank J., Cajulis, Elaina, Chung, Young-Ah, Tsai, Mei- Mei, Mitchell, Petia, Lu, John, Chen, Ching, Sun, Jilin, Radinsky, Robert, Kendall, Richard, Beltran, Pedro J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562316/
https://ncbi.nlm.nih.gov/pubmed/23383308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055135
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items