Epitope-Specific Mechanisms of IGF1R Inhibition by Ganitumab

BACKGROUND: Therapeutic antibodies targeting the IGF1R have shown diverse efficacy and safety signals in oncology clinical trials. The success of these agents as future human therapeutics depends on understanding the specific mechanisms by which these antibodies target IGF1R signaling. METHODOLOGY/P...

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Autores principales: Calzone, Frank J., Cajulis, Elaina, Chung, Young-Ah, Tsai, Mei- Mei, Mitchell, Petia, Lu, John, Chen, Ching, Sun, Jilin, Radinsky, Robert, Kendall, Richard, Beltran, Pedro J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562316/
https://ncbi.nlm.nih.gov/pubmed/23383308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055135
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