Epitope-Specific Mechanisms of IGF1R Inhibition by Ganitumab

BACKGROUND: Therapeutic antibodies targeting the IGF1R have shown diverse efficacy and safety signals in oncology clinical trials. The success of these agents as future human therapeutics depends on understanding the specific mechanisms by which these antibodies target IGF1R signaling. METHODOLOGY/P...

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Detalhes bibliográficos
Main Authors: Calzone, Frank J., Cajulis, Elaina, Chung, Young-Ah, Tsai, Mei- Mei, Mitchell, Petia, Lu, John, Chen, Ching, Sun, Jilin, Radinsky, Robert, Kendall, Richard, Beltran, Pedro J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562316/
https://ncbi.nlm.nih.gov/pubmed/23383308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055135
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