Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice

Increasing evidence suggests that TRB3, a mammalian homolog of Drosophila tribbles, plays an important role in cell growth, differentiation, and metabolism. In the liver, TRB3 binds and inhibits Akt activity, whereas in adipocytes, TRB3 upregulates fatty acid oxidation. In cultured muscle cells, TRB...

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Hlavní autoři: An, Ding, Lessard, Sarah J., Toyoda, Taro, Lee, Min-Young, Koh, Ho-Jin, Qi, Ling, Hirshman, Michael F., Goodyear, Laurie J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
Témata:
Physical Activity and Inactivity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159733/
https://ncbi.nlm.nih.gov/pubmed/24740654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00027.2014
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