Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice

Increasing evidence suggests that TRB3, a mammalian homolog of Drosophila tribbles, plays an important role in cell growth, differentiation, and metabolism. In the liver, TRB3 binds and inhibits Akt activity, whereas in adipocytes, TRB3 upregulates fatty acid oxidation. In cultured muscle cells, TRB...

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Bibliografske podrobnosti
Main Authors: An, Ding, Lessard, Sarah J., Toyoda, Taro, Lee, Min-Young, Koh, Ho-Jin, Qi, Ling, Hirshman, Michael F., Goodyear, Laurie J.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2014
Teme:
Physical Activity and Inactivity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159733/
https://ncbi.nlm.nih.gov/pubmed/24740654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00027.2014
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