Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice

Increasing evidence suggests that TRB3, a mammalian homolog of Drosophila tribbles, plays an important role in cell growth, differentiation, and metabolism. In the liver, TRB3 binds and inhibits Akt activity, whereas in adipocytes, TRB3 upregulates fatty acid oxidation. In cultured muscle cells, TRB...

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Bibliographic Details
Main Authors: An, Ding, Lessard, Sarah J., Toyoda, Taro, Lee, Min-Young, Koh, Ho-Jin, Qi, Ling, Hirshman, Michael F., Goodyear, Laurie J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
Subjects:
Physical Activity and Inactivity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159733/
https://ncbi.nlm.nih.gov/pubmed/24740654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00027.2014
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