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Ancestry and other genetic associations with plasma PCSK9 response to simvastatin
OBJECTIVE: Statins stimulate transcription of proprotein convertase subtilisin/kexin type 9 (PCSK9), a negative regulator of the low-density lipoprotein receptor (LDLR), thus blunting the cholesterol-lowering effects of statin treatment. Though there is inter-individual variation in PCSK9 statin res...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4159722/ https://ncbi.nlm.nih.gov/pubmed/25089948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000081 |
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