Individual and combined associations of genetic variants in CYP3A4, CYP3A5, and SLCO1B1 with simvastatin and simvastatin acid plasma concentrations

Our objective was to evaluate the associations of genetic variants affecting simvastatin (SV) and simvastatin acid (SVA) metabolism (CYP3A4*22 and CYP3A5*3) and transport (SLCO1B1 T521C) with 12-hour plasma SV and SVA concentrations. The variants were genotyped, and concentrations were quantified by...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Cardiovasc Pharmacol
Main Authors: Luzum, Jasmine A., Theusch, Elizabeth, Taylor, Kent D., Wang, Ann, Sadee, Wolfgang, Binkley, Philip F., Krauss, Ronald M., Medina, Marisa W., Kitzmiller, Joseph P.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503374/
https://ncbi.nlm.nih.gov/pubmed/26164721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000246
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker