Individual and combined associations of genetic variants in CYP3A4, CYP3A5, and SLCO1B1 with simvastatin and simvastatin acid plasma concentrations

Our objective was to evaluate the associations of genetic variants affecting simvastatin (SV) and simvastatin acid (SVA) metabolism (CYP3A4*22 and CYP3A5*3) and transport (SLCO1B1 T521C) with 12-hour plasma SV and SVA concentrations. The variants were genotyped, and concentrations were quantified by...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cardiovasc Pharmacol
Prif Awduron: Luzum, Jasmine A., Theusch, Elizabeth, Taylor, Kent D., Wang, Ann, Sadee, Wolfgang, Binkley, Philip F., Krauss, Ronald M., Medina, Marisa W., Kitzmiller, Joseph P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503374/
https://ncbi.nlm.nih.gov/pubmed/26164721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000246
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg