The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Bone marrow transplantation is the primary therapy for numerous hematopoietic disorders. The efficiency of bone marrow transplantation depends on the function of long-term hematopoietic stem cells (LT-HSCs), which is markedly influenced by their hypoxic niche. Survival in this low-oxygen microenviro...

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Hlavní autoři: Simsek, Tugba, Kocabas, Fatih, Zheng, Junke, DeBerardinis, Ralph J., Mahmoud, Ahmed I., Olson, Eric N., Schneider, Jay W., Zhang, Cheng Cheng, Sadek, Hesham A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159713/
https://ncbi.nlm.nih.gov/pubmed/20804973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.07.011
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