PF-4708671 Activates AMPK Independently of p70S6K1 Inhibition

The P70 ribosomal protein S6 kinase 1 (P70S6K1) is activated by the mammalian target of rapamycin (mTORC1) and regulates proliferation, growth, and metabolism. PF-4708671 is a novel, cell-permeable, has been proposed to be a highly specific inhibitor of p70S6K1. It is used in micromolar concentratio...

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Main Authors: Vainer, Gilad W., Saada, Ann, Kania-Almog, Juliane, Amartely, Adir, Bar-Tana, Jacob, Hertz, Rachel
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159345/
https://ncbi.nlm.nih.gov/pubmed/25202971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107364
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