G(i) Proteins Regulate Adenylyl Cyclase Activity Independent of Receptor Activation

BACKGROUND AND PURPOSE: Despite the view that only β(2)- as opposed to β(1)-adrenoceptors (βARs) couple to G(i), some data indicate that the β(1)AR-evoked inotropic response is also influenced by the inhibition of G(i). Therefore, we wanted to determine if G(i) exerts tonic receptor-independent inhi...

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Hauptverfasser: Melsom, Caroline Bull, Ørstavik, Øivind, Osnes, Jan-Bjørn, Skomedal, Tor, Levy, Finn Olav, Krobert, Kurt Allen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159282/
https://ncbi.nlm.nih.gov/pubmed/25203113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106608
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