Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence

Oncogenic RAS (H-RAS(V12)) induces premature senescence in primary cells by triggering production of reactive oxygen species (ROS), but the molecular role of ROS in senescence remains elusive. We investigated whether inhibition of protein tyrosine phosphatases by ROS contributed to H-RAS(V12)-induce...

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Detalhes bibliográficos
Main Authors: Yang, Ming, Haase, Astrid D., Huang, Fang-Ke, Coulis, Gérald, Rivera, Keith D., Dickinson, Bryan C., Chang, Christopher J., Pappin, Darryl J., Neubert, Thomas A., Hannon, Gregory J., Boivin, Benoit, Tonks, Nicholas K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159145/
https://ncbi.nlm.nih.gov/pubmed/25175024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.07.018
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