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Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation

Somatic mutations in the RAS genes are frequent in human tumors, especially in pancreatic, colorectal, and non-small-cell lung cancers. Such mutations generally decrease the ability of Ras to hydrolyze GTP, maintaining the protein in a constitutively active GTP-bound form that drives uncontrolled ce...

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Bibliografiske detaljer
Udgivet i:Cancer Metastasis Rev
Main Authors: Buday, László, Vas, Virág
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680326/
https://ncbi.nlm.nih.gov/pubmed/32936431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10555-020-09918-2
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