Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation

The conserved eukaryotic Pan2–Pan3 deadenylation complex shortens cytoplasmic mRNA 3′ polyA tails to regulate mRNA stability. Although the exonuclease activity resides in Pan2, efficient deadenylation requires Pan3. The mechanistic role of Pan3 is unclear. Here, we show that Pan3 binds RNA directly...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Wolf, Jana, Valkov, Eugene, Allen, Mark D, Meineke, Birthe, Gordiyenko, Yuliya, McLaughlin, Stephen H, Olsen, Tayla M, Robinson, Carol V, Bycroft, Mark, Stewart, Murray, Passmore, Lori A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
Soggetti:
Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158885/
https://ncbi.nlm.nih.gov/pubmed/24872509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488373
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi