Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation

The conserved eukaryotic Pan2–Pan3 deadenylation complex shortens cytoplasmic mRNA 3′ polyA tails to regulate mRNA stability. Although the exonuclease activity resides in Pan2, efficient deadenylation requires Pan3. The mechanistic role of Pan3 is unclear. Here, we show that Pan3 binds RNA directly...

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Main Authors: Wolf, Jana, Valkov, Eugene, Allen, Mark D, Meineke, Birthe, Gordiyenko, Yuliya, McLaughlin, Stephen H, Olsen, Tayla M, Robinson, Carol V, Bycroft, Mark, Stewart, Murray, Passmore, Lori A
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158885/
https://ncbi.nlm.nih.gov/pubmed/24872509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488373
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