Degrasyn-like Symmetrical Compounds: Possible Therapeutic Agents for Multiple Myeloma (MM-I)

A series of degrasyn-like symmetrical compounds have been designed, synthesized, and screened against B cell malignancy (multiple myeloma, mantle cell lymphoma) cell lines. The lead compounds T5165804 and CP2005 showed higher nanomolar potency against these tumor cells in comparison to degrasyn and...

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Auteurs principaux: Peng, Zhenghong, Maxwell, David, Sun, Duoli, Bhanu Prasad, Basvoju A., Schuber, Paul T., Pal, Ashutosh, Ying, Yunming, Han, Dongmei, Gao, Liwei, Wang, Shimei, Levitzki, Alexander, Kapuria, Vaibhav, Talpaz, Moshe, Young, Matthew, Showalter, Hollis D., Donato, Nicholas J., Bornmann, William. G.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158738/
https://ncbi.nlm.nih.gov/pubmed/24457091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.12.048
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