Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [(131)I] analogue as useful PET tracers for PI3-kinase

An improved method for the synthesis of 17β-hydroxy-16α-iodo-wortmannin along with the first synthesis of 17β-hydroxy-16α-iodoPX866 and [(131)I] radiolabeled 17β-hydroxy-16α-[(131)I]iodo-wortmannin, as potential PET tracers for PI3K was also described. The differences between wortmannin and its iodo...

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Autors principals: Sun, Duoli, Bhanu Prasad, Basvoju A., Schuber, Paul T., Peng, Zhenghong, Maxwell, David S., Martin, Diana V., Guo, Liwei, Han, Dongmei, Kurihara, Hiroaki, Yang, David J., Gelovani, Juri G., Powis, Garth, Bornmann, William G.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960976/
https://ncbi.nlm.nih.gov/pubmed/23859776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.06.036
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