Target-Based Therapeutic Matching in Early-Phase Clinical Trials in Patients with Advanced Colorectal Cancer and PIK3CA mutations

Target-matched treatment with PI3K/AKT/mTOR pathway inhibitors in patients with diverse advanced cancers with PIK3CA mutations have shown promise. Tumors from patients with colorectal cancer (CRC) were analyzed for PIK3CA, KRAS and BRAF mutations. PIK3CA mutated tumors were treated, whenever feasibl...

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Detalhes bibliográficos
Main Authors: Ganesan, Prasanth, Janku, Filip, Naing, Aung, Hong, David S., Tsimberidou, Apostolia M., Falchook, Gerald S., Wheler, Jennifer J., Piha-Paul, Sarina A., Fu, Siqing, Stepanek, Vanda M., Lee, J. Jack, Luthra, Rajyalakshmi, Overman, Michael J., Kopetz, E. Scott, Wolff, Robert A, Kurzrock, Razelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158732/
https://ncbi.nlm.nih.gov/pubmed/24092809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0319-T
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