Target-Based Therapeutic Matching in Early-Phase Clinical Trials in Patients with Advanced Colorectal Cancer and PIK3CA mutations

Target-matched treatment with PI3K/AKT/mTOR pathway inhibitors in patients with diverse advanced cancers with PIK3CA mutations have shown promise. Tumors from patients with colorectal cancer (CRC) were analyzed for PIK3CA, KRAS and BRAF mutations. PIK3CA mutated tumors were treated, whenever feasibl...

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Main Authors: Ganesan, Prasanth, Janku, Filip, Naing, Aung, Hong, David S., Tsimberidou, Apostolia M., Falchook, Gerald S., Wheler, Jennifer J., Piha-Paul, Sarina A., Fu, Siqing, Stepanek, Vanda M., Lee, J. Jack, Luthra, Rajyalakshmi, Overman, Michael J., Kopetz, E. Scott, Wolff, Robert A, Kurzrock, Razelle
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158732/
https://ncbi.nlm.nih.gov/pubmed/24092809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0319-T
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