Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy

There are several major pathological changes in Alzheimer's disease, including apoptosis of cholinergic neurons, overactivity or overexpression of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and inflammation. In this study, we synthesized a 19-nt oligonucleotide targeting BACE1,...

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Detalhes bibliográficos
Main Authors: Liu, Zhonghua, Li, Shengliang, Liang, Zibin, Zhao, Yan, Zhang, Yulin, Yang, Yaqi, Wang, Minjuan, Li, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2013
Assuntos:
Research and Report Article: Neurodegenerative Disease and Neural Regeneration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158703/
https://ncbi.nlm.nih.gov/pubmed/25206630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3969/j.issn.1673-5374.2013.33.003
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