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β-Secretases, Alzheimer's Disease, and Down Syndrome

Individuals with Down Syndrome (DS), or trisomy 21, develop Alzheimer's disease (AD) pathology by approximately 40 years of age. Chromosome 21 harbors several genes implicated in AD, including the amyloid precursor protein and one homologue of the β-site APP cleaving enzyme, BACE2. Processing o...

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Podrobná bibliografie
Hlavní autoři: Webb, Robin L., Murphy, M. Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299320/
https://ncbi.nlm.nih.gov/pubmed/22481915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/362839
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