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Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa
BACKGROUND: A patient with factor XI (fXI) deficiency was reported with an Arg184Gly substitution in the fXI A3 domain. The A3 domain contains an exosite required for binding of factor IX (fIX) to activated fXI (fXIa). OBJECTIVE: To test the effects of the Arg184Gly substitution on fIX activation, a...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4158700/ https://ncbi.nlm.nih.gov/pubmed/23617568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12275 |
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