Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival

Prostate apoptosis response protein 4 (Par-4) also known as PRKC apoptosis WT1 regulator is a tumor suppressor that selectively induces apoptosis in cancer cells. However, its post-translational regulation by ubiquitin-mediated proteolysis and the cellular machinery that is responsible for its prote...

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Bibliografiske detaljer
Main Authors: Chen, X, Sahasrabuddhe, A A, Szankasi, P, Chung, F, Basrur, V, Rangnekar, V M, Pagano, M, Lim, M S, Elenitoba-Johnson, K S J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158693/
https://ncbi.nlm.nih.gov/pubmed/24992930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.92
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