Recombinant Respiratory Syncytial Viruses Lacking the C-Terminal Third of the Attachment (G) Protein Are Immunogenic and Attenuated In Vivo and In Vitro

The design of attenuated vaccines for respiratory syncytial virus (RSV) historically focused on viruses made sensitive to physiologic temperature through point mutations in the genome. These prototype vaccines were not suitable for human infants primarily because of insufficient attenuation, genetic...

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Main Authors: Elliott, Matthew B., Pryharski, Karin S., Yu, Qingzhong, Parks, Christopher L., Laughlin, Todd S., Gupta, C. Kanta, Lerch, Robert A., Randolph, Valerie B., LaPierre, Natisha A., Heers Dack, Kristen M., Hancock, Gerald E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC415824/
https://ncbi.nlm.nih.gov/pubmed/15140975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.11.5773-5783.2004
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