Recombinant Respiratory Syncytial Viruses Lacking the C-Terminal Third of the Attachment (G) Protein Are Immunogenic and Attenuated In Vivo and In Vitro

The design of attenuated vaccines for respiratory syncytial virus (RSV) historically focused on viruses made sensitive to physiologic temperature through point mutations in the genome. These prototype vaccines were not suitable for human infants primarily because of insufficient attenuation, genetic...

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Detalhes bibliográficos
Main Authors: Elliott, Matthew B., Pryharski, Karin S., Yu, Qingzhong, Parks, Christopher L., Laughlin, Todd S., Gupta, C. Kanta, Lerch, Robert A., Randolph, Valerie B., LaPierre, Natisha A., Heers Dack, Kristen M., Hancock, Gerald E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC415824/
https://ncbi.nlm.nih.gov/pubmed/15140975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.11.5773-5783.2004
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