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Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: a critical role of the Notch1–NF-κB pathway in BMP-2 expression

Calcific aortic valve disease (CAVD) is a chronic inflammatory condition and affects a large number of elderly people. Aortic valve interstitial cells (AVICs) occupy an important role in valvular calcification and CAVD progression. While pro-inflammatory mechanisms are capable of inducing the osteog...

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Autori principali: Wang, Dong, Zeng, Qingchun, Song, Rui, Ao, Lihua, Fullerton, David A., Meng, Xianzhong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157971/
https://ncbi.nlm.nih.gov/pubmed/25101972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2014.07.017
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