Activation of TLR3 Induces Osteogenic Responses in Human Aortic Valve Interstitial Cells through the NF-κB and ERK1/2 Pathways

Calcific aortic valve disease (CAVD) is characterized by chronic inflammation and progressive calcification in valve leaflets. Aortic valve interstitial cells (AVICs) play a critical role in the pathogenesis of CAVD. Previous studies show that stimulation of Toll-like receptor (TLR) 2 or TLR4 in AVI...

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Vydáno v:Int J Biol Sci
Hlavní autoři: Zhan, Qiong, Song, Rui, Zeng, Qingchun, Yao, Qingzhou, Ao, Lihua, Xu, Dingli, Fullerton, David A., Meng, Xianzhong
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366646/
https://ncbi.nlm.nih.gov/pubmed/25798067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.10905
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