Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-κB pathway

Calcific aortic valve disease is a chronic inflammatory condition, and the inflammatory responses of aortic valve interstitial cells (AVICs) play a critical role in the disease progression. Double-stranded RNA (dsRNA) released from damaged or stressed cells is proinflammatory and may contribute to t...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Zhan, Qiong, Song, Rui, Li, Fei, Ao, Lihua, Zeng, Qingchun, Xu, Dingli, Fullerton, David A., Meng, Xianzhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407013/
https://ncbi.nlm.nih.gov/pubmed/28052863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00230.2016
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