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Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and NF-κB activation

OBJECTIVE: Calcific aortic valve disease is a leading cardiovascular disease in the elderly, and progressive calcification results in the failure of valvular function. Aortic valve interstitial cells (AVICs) from stenotic valves express higher levels of bone morphogenetic protein-2 (BMP-2) in respon...

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Bibliografiske detaljer
Main Authors: Zeng, Qingchun, Song, Rui, Ao, Lihua, Weyant, Michael J., Lee, Joon, Xu, Dingli, Fullerton, David A., Meng, Xianzhong
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778193/
https://ncbi.nlm.nih.gov/pubmed/23640488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300912
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