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Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and NF-κB activation
OBJECTIVE: Calcific aortic valve disease is a leading cardiovascular disease in the elderly, and progressive calcification results in the failure of valvular function. Aortic valve interstitial cells (AVICs) from stenotic valves express higher levels of bone morphogenetic protein-2 (BMP-2) in respon...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3778193/ https://ncbi.nlm.nih.gov/pubmed/23640488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300912 |
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