Degradation of p53, Not Telomerase Activation, by E6 Is Required for Bypass of Crisis and Immortalization by Human Papillomavirus Type 16 E6/E7

Bypass of two arrest points is essential in the process of cellular immortalization, one of the components of the transformation process. Expression of human papillomavirus type 16 E6 and E7 together can escape both senescence and crisis, processes which normally limit the proliferative capacity of...

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Bibliographic Details
Main Authors: McMurray, H. R., McCance, D. J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Transformation and Oncogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC415791/
https://ncbi.nlm.nih.gov/pubmed/15140967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.11.5698-5706.2004
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