Chromatin Accessibility Mapping Identifies Mediators of Basal Transcription and Retinoid-Induced Repression of OTX2 in Medulloblastoma

Despite an emerging understanding of the genetic alterations giving rise to various tumors, the mechanisms whereby most oncogenes are overexpressed remain unclear. Here we have utilized an integrated approach of genomewide regulatory element mapping via DNase-seq followed by conventional reporter as...

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Detalhes bibliográficos
Main Authors: Wortham, Matthew, Guo, Changcun, Zhang, Monica, Song, Lingyun, Lee, Bum-Kyu, Iyer, Vishwanath R., Furey, Terrence S., Crawford, Gregory E., Yan, Hai, He, Yiping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157845/
https://ncbi.nlm.nih.gov/pubmed/25198066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107156
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