Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

Pluripotent stem cells exist in naive and primed states, epitomized by mouse embryonic stem cells (ESCs) and the developmentally more advanced epiblast stem cells (EpiSCs; ref. 1). In the naive state of ESCs, the genome has an unusual open conformation and possesses a minimum of repressive epigeneti...

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Bibliographic Details
Main Authors: Berge, Derk ten, Kurek, Dorota, Blauwkamp, Tim, Koole, Wouter, Maas, Alex, Eroglu, Elif, Siu, Ronald K., Nusse, Roel
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157727/
https://ncbi.nlm.nih.gov/pubmed/21841791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2314
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