MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN/AKT in human airway smooth muscle cells

BACKGROUND: The cell-surface protein CD38 mediates airway smooth muscle (ASM) contractility by generating cyclic ADP-ribose, a calcium-mobilizing molecule. In human ASM cells, TNF-α augments CD38 expression transcriptionally by NF-κB and AP-1 activation and involving MAPK and PI3K signaling. CD38(−/...

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Main Authors: Dileepan, Mythili, Jude, Joseph A, Rao, Savita P, Walseth, Timothy F, Panettieri, Reynold A, Subramanian, Subbaya, Kannan, Mathur S
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156970/
https://ncbi.nlm.nih.gov/pubmed/25175907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-014-0107-0
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