Differential induction of CD38 expression by TNF-α in asthmatic airway smooth muscle cells

The ADP-ribosyl cyclase activity of CD38, a membrane protein expressed in human airway smooth muscle (ASM) cells, generates cyclic ADP-ribose (cADPR), a Ca(2+)-mobilizing agent. cADPR-mediated Ca(2+) responses to agonists are augmented in human ASM cells by TNF-α. CD38-deficient mice fail to develop...

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Bibliographic Details
Main Authors: Jude, Joseph A., Solway, Julian, Panettieri, Reynold A., Walseth, Timothy F., Kannan, Mathur S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006261/
https://ncbi.nlm.nih.gov/pubmed/20693316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00021.2010
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