Altered CD38/Cyclic ADP-Ribose Signaling Contributes to the Asthmatic Phenotype

CD38 is a transmembrane glycoprotein expressed in airway smooth muscle cells. The enzymatic activity of CD38 generates cyclic ADP-ribose from β-NAD. Cyclic ADP-ribose mobilizes intracellular calcium during activation of airway smooth muscle cells by G-protein-coupled receptors through activation of...

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Bibliographic Details
Main Authors: Jude, Joseph A., Dileepan, Mythili, Panettieri, Reynold A., Walseth, Timothy F., Kannan, Mathur S.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508580/
https://ncbi.nlm.nih.gov/pubmed/23213344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/289468
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