Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro

Recent data show that colon cancer cells selectively overexpress cystathionine-β-synthase (CBS), which produces hydrogen sulfide (H(2)S), to maintain cellular bioenergetics, support tumor growth and stimulate angiogenesis and vasorelaxation in the tumor microenvironment. The purpose of the current s...

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Bibliographic Details
Main Authors: Módis, Katalin, Coletta, Ciro, Asimakopoulou, Antonia, Szczesny, Bartosz, Chao, Celia, Papapetropoulos, Andreas, Hellmich, Mark R., Szabo, Csaba
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156891/
https://ncbi.nlm.nih.gov/pubmed/24667534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2014.03.001
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