PTPN14 Forms a Complex with Kibra and LATS1 Proteins and Negatively Regulates the YAP Oncogenic Function

The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Pivotal effectors of this pathway are YAP/TAZ, transcriptional co-activators whose dysfunction contributes to epithelial-to-mesenchymal transition and mali...

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Bibliographic Details
Main Authors: Wilson, Kayla E., Li, Ying-Wei, Yang, Nuo, Shen, He, Orillion, Ashley R., Zhang, Jianmin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156080/
https://ncbi.nlm.nih.gov/pubmed/25023289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.534701
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