Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome Assembly

Inflammasomes are macromolecular complexes that mediate inflammatory and cell death responses to pathogens and cellular stress signals. Dysregulated inflammasome activation is associated with autoinflammatory syndromes and several common diseases. During inflammasome assembly, oligomerized cytosolic...

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Bibliografske podrobnosti
Main Authors: Vajjhala, Parimala R., Kaiser, Sebastian, Smith, Sarah J., Ong, Qi-Rui, Soh, Stephanie L., Stacey, Katryn J., Hill, Justine M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156052/
https://ncbi.nlm.nih.gov/pubmed/25006247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.553305
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