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Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein

A key process underlying an innate immune response to pathogens or cellular stress is activation of members of the NOD-like receptor family, such as NLRP3, to assemble caspase-1-activating inflammasome complexes. Activated caspase-1 processes proinflammatory cytokines into active forms that mediate...

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Detalhes bibliográficos
Main Authors: Vajjhala, Parimala R., Mirams, Ruth E., Hill, Justine M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516722/
https://ncbi.nlm.nih.gov/pubmed/23066025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.381228
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