Biophysical Optimization of a Therapeutic Protein by Nonstandard Mutagenesis: STUDIES OF AN IODO-INSULIN DERIVATIVE

Insulin provides a model for the therapeutic application of protein engineering. A paradigm in molecular pharmacology was defined by design of rapid-acting insulin analogs for the prandial control of glycemia. Such analogs, a cornerstone of current diabetes regimens, exhibit accelerated subcutaneous...

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Bibliographic Details
Main Authors: Pandyarajan, Vijay, Phillips, Nelson B., Cox, Gabriela P., Yang, Yanwu, Whittaker, Jonathan, Ismail-Beigi, Faramarz, Weiss, Michael A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156050/
https://ncbi.nlm.nih.gov/pubmed/24993826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.588277
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