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Ciprofloxacin Dimers Target Gyrase in Streptococcus pneumoniae
We have examined the antipneumococcal activities of novel quinolone dimers in which ciprofloxacin was tethered to itself or to pipemidic acid by linkage of C-7 piperazinyl rings. Symmetric 2,6-lutidinyl- and trans-butenyl-linked ciprofloxacin dimers (dimers 1 and 2, respectively) and a pipemidic aci...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2004
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC415600/ https://ncbi.nlm.nih.gov/pubmed/15155208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.6.2108-2115.2004 |
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