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Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα)

The serine/threonine protein kinase Akt promotes cell survival, growth, and proliferation through phosphorylation of different downstream substrates. A key effector of Akt is the mammalian target of rapamycin (mTOR). Akt is known to stimulate mTORC1 activity through phosphorylation of tuberous scler...

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Bibliografski detalji
Glavni autori: Dan, Han C., Ebbs, Aaron, Pasparakis, Manolis, Van Dyke, Terry, Basseres, Daniela S., Baldwin, Albert S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155685/
https://ncbi.nlm.nih.gov/pubmed/24990947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554881
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