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PI3K/Akt promotes feedforward mTORC2 activation through IKKα
The ser-thr Akt plays a critical role in the regulation of cell survival, cell growth and proliferation, as well as energy metabolism and is dysregulated in many cancers. The regulation of Akt activity depends on the phosphorylation at two sites: (i) Thr308 in the activation loop by phosphoinositide...
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| Veröffentlicht in: | Oncotarget |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Impact Journals LLC
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5008269/ https://ncbi.nlm.nih.gov/pubmed/27027448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8383 |
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