Voriconazole plasma concentrations in immunocompromised pediatric patients vary by CYP2C19 diplotypes

AIM: Our objective was to describe the association between voriconazole concentrations and CYP2C19 diplotypes in pediatric cancer patients, including children homozygous for the CYP2C19*17 gain-of-function allele. MATERIALS & METHODS: A linear mixed effect model compared voriconazole dose-correc...

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Detalhes bibliográficos
Main Authors: Hicks, J Kevin, Crews, Kristine R, Flynn, Patricia, Haidar, Cyrine E, Daniels, Calvin C, Yang, Wenjian, Panetta, John C, Pei, Deqing, Scott, Jeffrey R, Molinelli, Alejandro R, Broeckel, Ulrich, Bhojwani, Deepa, Evans, William E, Relling, Mary V
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155516/
https://ncbi.nlm.nih.gov/pubmed/25084200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.14.53
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