Identification of CYP2D6 Haplotypes that Interfere with Commonly Used Assays for Copy Number Variation Characterization

Cytochrome P450 2D6 (CYP2D6) copy number (CN) variation affects the metabolism of numerous prescribed drugs. Sequence variation within primer or probe target regions of hydrolysis probe CN assays can generate false-positive calls for CN loss. Furthermore, CYP2D6–CYP2D7 hybrids and gene conversions c...

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Vydáno v:J Mol Diagn
Hlavní autoři: Turner, Amy J., Aggarwal, Praful, Boone, Erin C., Haidar, Cyrine-Eliana, Relling, Mary V., Derezinski, Ashley D., Broeckel, Ulrich, Gaedigk, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2021
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176139/
https://ncbi.nlm.nih.gov/pubmed/33631352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2021.01.013
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