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Endogenous RNA interference is driven by copy number

A plethora of non-protein coding RNAs are produced throughout eukaryotic genomes, many of which are transcribed antisense to protein-coding genes and could potentially instigate RNA interference (RNAi) responses. Here we have used a synthetic RNAi system to show that gene copy number is a key factor...

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Hlavní autoři: Cruz, Cristina, Houseley, Jonathan
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918874/
https://ncbi.nlm.nih.gov/pubmed/24520161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01581
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