Synthetic lethality in ATM-deficient RAD50-mutant tumors underlie outlier response to cancer therapy

Metastatic solid tumors are almost invariably fatal. Patients with disseminated small-cell cancers have a particularly unfavorable prognosis with most succumbing to their disease within two years. Here, we report on the genetic and functional analysis of an outlier curative response of a patient wit...

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Main Authors: Al-Ahmadie, Hikmat, Iyer, Gopa, Hohl, Marcel, Asthana, Saurabh, Inagaki, Akiko, Schultz, Nikolaus, Hanrahan, Aphrothiti J., Scott, Sasinya N., Brannon, A. Rose, McDermott, Gregory C., Pirun, Mono, Ostrovnaya, Irina, Kim, Philip, Socci, Nicholas D., Viale, Agnes, Schwartz, Gary K., Reuter, Victor, Bochner, Bernard H., Rosenberg, Jonathan E., Bajorin, Dean F., Berger, Michael F., Petrini, John H.J., Solit, David B., Taylor, Barry S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155059/
https://ncbi.nlm.nih.gov/pubmed/24934408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0380
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